Liver function tests as indicators of metabolic syndrome

Liver function tests as indicators of metabolic syndrome

Nonalcoholic fatty liver disease (NAFLD) is no longer considered to be a normal physiologic condition without any clinical significance. It is now widely accepted that nonalcoholic steatohepatitis (NASH), a type of fatty liver disease, can progress to end-stage liver disease and increase the risk of mortality. In addition, NAFLD patients are associated with a significantly higher overall mortal...

Effect of Ramadan Fast on Liver Function Tests

Effect of fibrate treatment on liver function tests in patients with the metabolic syndrome

BACKGROUND Fibrates are used especially in patients with hypertriglyceridaemia, a feature of the metabolic syndrome. Elevated LFTs are often observed in these patients perhaps related to fatty infiltration. AIM We wished to study changes seen in LFTs (GGT, ALT and ALP) following fibrate therapy and then determine associated factors. METHODS This was a retrospective observational study in wh...

Evaluation of Adiposity-Related Biomarkers as Metabolic Syndrome Indicators

Recent studies have suggested a relationship of the increased circulating adipokines and inflammatory cytokine, and the risk of metabolic syndrome (MetS). The objective of this study was to identify adiposity-related factors that reflect MetS in order to establish early intervention targets. We performed a cross-sectional study which included 108 MetS subjects and 91 controls. Blood adiponectin...

Abnormal liver function tests and metabolic syndrome--is fatty liver related to risks for atherosclerosis beyond obesity?

Oda and colleagues (1) reported that elevated liver enzymes, such as alanine aminotransferase (ALT) and gammaglutamyltransferase (GGT), are related to metabolic syndrome (MetS) in Japanese men and women. One of the main causes of abnormal liver function is fatty liver disease. Recently, it was reported that non-alcoholic fatty liver disease (NAFLD) is related to cardiovascular disease (CVD) (2-...